Drug for today is desonide.
What is desonide indicated for?
INDICATIONS :
- It is a topical corticosteroid as 0.05% cream, ointment or lotion.
- It is indicated for the treatment of mild to moderate atopic dermatitis in patients 3 months of age and older. (A skin disease characterized by areas of severe itching, redness, scaling, and loss of the surface of the skin.)
How does desonide work?
MECHANISMS OF ACTION :
- It is a topical corticosteroids which share anti-inflammatory, antipruritic and vasoconstrictive properties.
- The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
ROUTE OF ADMINISTRATION :
- It is for topical use only. Not for oral, ophthalmic, or intravaginal use.
- Apply a thin layer to the affected areas two to four times daily and rub in gently.
- Discontinue use when control is achieved. If no improvement is seen within 4 weeks, reassessment of diagnosis may be necessary. Treatment beyond 4 consecutive weeks is not recommended.
- Do not use with occlusive dressings.
- Treated skin area should not be bandaged or otherwise covered or wrapped.
- Avoid contact with eyes or other mucous membranes.
Are there any possible side effects?
SIDE EFFECTS :
(i) Common possible side effects :
- burning
- itching
- rashes
- headache
- folliculitis
- acneiform eruptions
- hypopigmentation
- perioral dermatitis (skin disorder in which tiny red bumps form around the mouth.)
- secondary infection
- skin atrophy (a condition that leads to paper thin skin in older people.)
- striae
- miliaria (skin disease marked by small and itchy rashes.)
PRECAUTIONS :
- Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment.
- Manifestations of Cushing's syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment.
- Conditions which augment systemic absorption include the application of topical corticosteroids, over large body surface areas, prolonged use, or the addition of occlusive dressings. Therefore, patients applying a topical corticosteroid to a large body surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression.
- If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid.
- Recovery of HPA axis function is generally prompt and complete upon discontinuation of topical corticosteroids.
- Infrequently, signs and symptoms of glucocorticosteroid insufficiency may occur, requiring supplemental systemic corticosteroids.
Pregnancy and breastfeeding:
- There are no adequate and well-controlled studies in pregnant women. Therefore, desonide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Because many drugs are excreted in human milk, caution should be exercised when desonide is administered to a nursing woman.
References :
1 comments:
Desonide Cream is the best for eczema.
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